LADDER was developed by the ASF and Dup15q Alliance, in partnership with RTI International, in response to a critical need for a centralized database to collect and manage information provided by parents, caregivers, clinicians, and researchers about the natural history and clinical needs of patients with Angelman or Dup15q syndromes.

LADDER provides a mechanism to combine data from caregiver surveys, the Angelman Syndrome Natural History Study, the ASF and Dup15q Alliance registries, other Angelman or Dup15q targeted research studies, and specialty clinics (ASF clinics and Dup15q clinics) in the LADDER Learning Network (formerly known as the 15q Clinical Research Network (CRN)). LADDER also works in harmony with the Global Angelman Syndrome Registry to streamline efforts and maximize the potential for moving treatment development forward.

Although LADDER works closely with these data collection sources, it does not replace them. Rather, individuals or families who enroll their loved ones with Angelman or Dup15q syndromes in LADDER can be assured that the information they provide to any of these sources will be used to promote improved quality of life for individuals living with these conditions.